Involvement of Actin Microfilaments in the Replication of Human Parainfluenza Virus Type 3

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Involvement of actin microfilaments in the replication of human parainfluenza virus type 3.

Several studies indicate that paramyxoviruses require a specific cellular factor(s) for transcription of their genomic RNAs. We previously reported that the cellular cytoskeletal protein actin, in its polymeric form, participates in the transcription of human parainfluenza virus type 3 (HPIV3) in vitro. In the present study, we investigated the role of the polymeric form of actin, i.e., the act...

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Human parainfluenza virus type 3 transcription in vitro: role of cellular actin in mRNA synthesis.

Purified ribonucleoprotein complexes of human parainfluenza virus type 3 (HPIV-3) virions required, in addition to the viral proteins, soluble cytoplasmic proteins from uninfected cells for the synthesis of mRNAs in vitro. In contrast to Sendai virus transcription, in vitro RNA synthesis from HPIV-3 ribonucleoprotein complexes was not stimulated significantly by purified tubulin. Moreover, cyto...

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Human Parainfluenza Virus Type 3 in Wild Nonhuman Primates, Zambia

Human parainfluenza virus type 3 (HPIV3) genome was detected in 4 baboons in Zambia. Antibody for HPIV3 was detected in 13 baboons and 6 vervet monkeys in 2 distinct areas in Zambia. Our findings suggest that wild nonhuman primates are susceptible to HPIV3 infection.

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Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity.

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1998

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.72.4.2655-2662.1998